Malaysian Applied Biology Journal

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28-1&2-13

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Malays. Appl. Biol. (1999) 28(1&2): 73-77

IMMUNOSTIMULATORY EFFECTS OF LEVAMISOLE AND EGG WHITE POWDER ON HUMORAL AND CELLULAR IMMUNITY TO NEWCASTLE DISEASE VACCINATION

ABDALLA,M.O.1, MOHAMMED,M.E.H.1, ALI, A.S.1*, MUKHTAR, M.M.2 and MOHD-AZMI,M.L.3

1Department of Preventive Medicine and Public Health, Faculty of Veterinary Science,
P.O. Box 32, Khartoum North, University of Khartoum, Sudan
2Department of Molecular Biology, Institute of Endemic Diseases, P.O. Box 11463, Khartoum, University of Khartoum, Sudan
3Faculty of Veterinary Medicine Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.

ABSTRACT

Both humoral and cellular immune responses following administration of Levamisole or egg white powder (EWP) ir Newcastle disease (ND) vaccinated chickens were measured. Haemagglutination inhibition test to measure humoral immunity and lymphocyte proliferation assay to measure the cellular immunity were used. Both groups of chickens (those receiving Levamisole and EWP preparation) showed high haemagglutinating antibody response especially on day 20 post-vaccination. However, Levamisole treatment resulted in higher antibody response compared to EWP. The immunomodulatory effect of EWP on cell-mediated immunity, as measured by lymphocyte proliferation, was better than that due to Levamisole especially when measured 18 days post-vaccination.


Key words: antibody, cell-mediated immunity, egg white powder, Levamisole, Newcastle disease virus

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