Malays. Appl. Biol. (2018) 47(1): 181–187
EARLY CARDIOVASCULAR MRI POST SUCCESSFUL
REPERFUSION OF ACUTE MYOCARDIAL INFARCTION:
AN EXPLORATORY STUDY
MOHD AMIN NOR HANIM2, SAID ASRI1,2*, KENG TAT KOH2, YEN YEE OON2,
FONG ALAN YEAN YIP2, YEE LING CHAM2, SIAN KONG TAN2, NING ZAN KHIEW2,
KUAN LEONG YEW2, CHI YEN VOON2 and TIONG KIAM ONG2
1Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia
2Department of Cardiology, Sarawak Heart Centre, Kota Samarahan, Malaysia
*E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Accepted 26 February 2018, Published online 31 March 2018
ABSTRACT
Post-myocardial infarction (MI) patients has varied outcome despite successful reperfusion. Our study aimed to use cardiac magnetic resonance imaging (CMR) to explore parameters that may influence outcome in successfully reperfused post-MI patients. We used left ventricular (LV) remodelling and major adverse cardiovascular event (MACE) at 6 months as a poor-outcome indicator. Consecutive patients admitted to Sarawak Heart Centre from Dec 2012 to Nov 2014 with acute anterior or inferior ST elevation MI were screened. A total of 101 patients with TIMI-3 flow were recruited. Patients underwent CMR imaging during the index admission, and another between 3 to 6 months later. LV remodelling occurred in 21.8% while microvascular obstruction (MVO) in 38.6% of patients. LV infarct size and MVO were significant in those who developed LV remodelling, while door-to-perfusion time and total-ischaemic time were not significantly different. MACE was significant in patients with larger infarcts but not significant in patients with MVO. LV infarct size was also significant in those who had reverse LV remodelling. These results suggest that early CMR measurement of infarct size and detection of MVO has the potential to predict LV improvement or deterioration at 6 months.
Key words: Cardiac mri, early post myocardial imaging, left ventricular remodelling, microvascular obstruction, post-acute myocardial infarction
