Malays. Appl. Biol. (2015) 44(3): 121-126
THE EFFECT OF Cosmos caudatus ON PLASMA CORTICOSTERONE LEVEL FOLLOWING A CHRONIC REPETITIVE FORCED SWIMMING STRESS IN RATS
Mohd Hadzrul Hisham, a.m.1, Osman, c.b.1, Ainsah, o.2, Rohaya, A.3, Aishah, A.4
1Faculty of Medicine, UiTM, Sungai Buloh Campus, Jln Hospital, 47000 Sg. Buloh, Selangor.
2Faculty of Medicine and Health’s Defence, UPNM, 57000Sg. Besi, Selangor
3Faculty of Applied Sciences, UiTM Shah Alam, 40450 Shah Alam.
4Faculty of Pharmacy, UiTM Puncak Alam, 42300 Bandar Puncak Alam, Selangor.
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Abstract
This study examines the effect of Cosmos caudatus on plasma corticosterone levels following a chronic repetitive forced swimming stress (FSS). Male Sprague-Dawley strains of rats weighing 90–120 g were used. The first group was the control, administered only with saline solution. Second and third groups received quercetin (100mg/kg and 200mg/kg) respectively, while the fourth and fifth groups were treated with C. caudatus’s extract (100mg/kg and 200mg/kg) respectively. The rats were subjected to FSS for 15 minutes daily. The tests revealed a significant reduction in plasma corticosterone level in all treated groups (except the second group) compared to the control. At the end of the experiment, the third, fourth and fifth groups had a reduction in plasma corticosterone level which were 153.950 nmol/l ± 2.98, 145.262 nmol/l ± 2.04, 134.488 nmol/l ± 2.70, respectively. The group treated with 200mg/kg of C. caudatus was most significant in reducing plasma corticosterone (p< 0.005). The present study suggests the ability of C. caudatus to reduce the plasma corticosterone level.
Keywords
Antioxidant, Cosmos caudatus, Chronic Stress, Corticosterone, Quercetin